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Comment: Barbiturates may well increase adverse effects, like respiratory despair, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.pentobarbital will reduce the extent or impact of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
pentobarbital will minimize the extent or influence of vincristine liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital will minimize the extent or influence of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.
pentobarbital will decrease the level or result of fosphenytoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Monitor.
Monitor Carefully (1)pentobarbital will decrease the extent or influence of mifepristone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers haven't been analyzed, coadministration not advisable by company
pentobarbital will decrease the extent or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.
pentobarbital will lessen the extent or effect of nelfinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
When the dose with the concomitant CYP3A4 inducer cannot be diminished or discontinued, implant removing could be necessary along with the individual should then be handled with website a buprenorphine dosage kind that permits dose adjustments. If a CYP3A4 inducer is discontinued within a individual who has long been stabilized on buprenorphine, monitor the patient for overmedication.
pentobarbital will minimize the extent or outcome of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. If coadministration with a CYP3A4 inducer is critical, contemplate raising oliceridine dose until stable drug effects are attained; check for indications of opioid withdrawal.
pentobarbital will reduce the level or result of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Observe Carefully (1)pentobarbital will decrease the level or effect of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the extent or result of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.
With therapeutic doses of TCAs, barbiturates boost metabolism and decrease blood concentrations of TCAs.